PQQ-Na2 Powder is a compound containing sodium salts, and its full name is disodium pyranoquinone dinucleotide salt. It is a compound comprising the coenzyme PQQ (pyrroloquinoline quinone) and sodium ions. At the chemical level, PQQ is a vitamin-like compound with a variety of critical biological functions. As a palladium ligand, it can enhance the catalytic activity of palladium compounds in redox reactions, thereby participating in a variety of biological processes and reactions. PQQ exists in most living organisms, including plants, animals, and microorganisms. PQQ Na2 contains two sodium ions, which makes it more soluble in water and also increases its stability. In the body, PQQ-Na2 can be quickly absorbed and bind to proteins in the blood to achieve its purpose.
PQQ Na2 has a variety of biological activities, the most important of which is its antioxidant properties. Free radicals are unstable molecules that cause oxidative stress and cell damage. PQQ-Na2 can scavenge these free radicals, thereby protecting cells from oxidative damage. This antioxidant property makes PQQ Na2 widely used in the medical field to protect cells from oxidative damage and may help prevent certain diseases. PQQ Na2 also regulates mitochondrial energy metabolism. Mitochondria are vital organs that produce energy in cells. PQQ Na2 can participate in the maintenance of mitochondrial function and the production of energy in cells, thus helping to maintain normal cellular metabolic processes. This property makes PQQ Na2 potentially valuable for enhancing physical fitness, improving cognitive function, and delaying aging.
Shaanxi Medibridge Biotech Co., Ltd. focuses on the supply of pharmaceutical raw materials and research-use compounds. We support customers with stable quality, clear specification communication, flexible packaging options, and document-related support for different project stages.
COA
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Product Name |
CAS Number |
Batch Number |
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PQQ-Na2 Powder |
122628-50-6 |
MB2608121655 |
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Manufacturer Date |
Analysis Date |
Expiry Date |
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2026/8/12 |
2026/8/13 |
2028/8/12 |
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Sample Qty Base |
Packing |
Test Method |
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600GS |
10GS/bottle |
HPLC |
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Item |
Standard |
Results |
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Appearance |
Red Powder |
Conform |
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Odor |
Characteristic |
Conform |
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Assay |
≥99.0% |
99.29% |
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Particle Size |
100% pass 80mesh |
Conform |
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Moisture |
<5.0% |
Conform |
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Ash Content |
<4.0% |
Conform |
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Solvent Residue |
Eur.Pharm |
Conform |
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Total Heavy Metals |
<10 ppm |
Conform |
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Arsenic |
<1.0 ppm |
Conform |
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Lead |
<1.0 ppm |
Conform |
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Mercury |
<0.5 ppm |
Conform |
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DDT |
<0.2ppm |
Conform |
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E. Coli |
Negative |
Negative |
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GMO Status |
Complies |
GMO Free |
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Irradiation |
Complies |
Irradiation Free |
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Conclusion |
The batch conforms to the IN-HOUSE standard |
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Redox Properties
The quinone structure of PQQ participates in electron transfer and can transition between oxidized and reduced states. This makes it useful for investigating redox reactions.
However, redox activity does not imply antioxidant behavior under every condition.
An original study found that PQQ protected isolated mitochondria against oxidative damage under the tested conditions. In cell culture, however, PQQ generated hydrogen peroxide through autoxidation in the medium and caused cellular injury; catalase inhibited this effect.
Enzymatic Functions
PQQ is a cofactor for certain microbial oxidoreductases. A well-characterized example is PQQ-dependent glucose dehydrogenase, which catalyzes glucose oxidation to gluconolactone. Structural studies have examined interactions among the enzyme, PQQ, and substrate.
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Research Area |
Principal Question |
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Apoenzyme reconstitution |
Does adding PQQ restore catalytic activity? |
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Metal-ion dependence |
How do components such as Ca²⁺ influence binding and activation? |
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Enzyme kinetics |
How does cofactor concentration affect reaction rate? |
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Electrochemical biosensing |
How are electrons transferred from the enzyme system to an electrode? |
Mitochondrial Biogenesis
Mitochondrial biogenesis is a major area of PQQ research.
An original cell study reported increased CREB phosphorylation, PGC-1α expression, and mitochondrial-associated measurements following PQQ exposure. Reducing CREB or PGC-1α expression prevented the biogenesis response, providing functional evidence for their involvement in that model.
The research framework can be summarized as:
PQQ exposure → CREB/PGC-1α-associated regulation → altered mitochondrial gene expression → assessment of mitochondrial abundance and function.
Another study investigated NAD⁺, SIRT1, and PGC-1α deacetylation, indicating that regulatory responses can differ between experimental systems.
Cytoprotection, Inflammation, and Tissue-Function Research
PQQ can support investigations connecting oxidative injury, inflammatory responses, and mitochondrial function.
For example, an original skeletal-muscle denervation study examined PQQ-associated changes in PGC-1α, respiratory-chain components, and muscle-atrophy endpoints. Such findings provide mechanistic information within a particular injury model; they do not directly establish muscle-building or performance benefits in healthy humans.
Metabolic Markers and Cognitive Endpoints
PQQ-Na₂ has been investigated in human nutritional-intervention studies, but their questions and endpoints should be interpreted separately.
- Metabolic and Inflammatory Measurements
One human study examined PQQ exposure alongside inflammatory markers and mitochondrial-related metabolic measurements. These findings help characterize human responses, but changes in metabolites do not directly demonstrate increased mitochondrial abundance in human tissues.
- Cognitive Research
Randomized, double-blind, placebo-controlled studies have examined cognitive performance in healthy middle-aged and older adults, including a 12-week investigation of PQQ disodium salt.
Interpretation should consider sample size, prespecified primary outcomes, the number of cognitive tests, practice effects, and independent replication. Results from combination products cannot be attributed entirely to PQQ.
FAQ
What is PQQ supplement used for?
PQQ (pyrroloquinoline quinone) supplements are primarily used to support cellular energy production, brain health, and antioxidant defense.
Is PQQ hard on kidneys?
PQQ (pyrroloquinoline quinone) is generally considered safe for the kidneys at standard supplemental doses.
Can I take PQQ every day?
Yes, you can take PQQ (pyrroloquinoline quinone) every day.
What are the side effects of taking PQQ?
Taking PQQ (pyrroloquinoline quinone) supplements can cause mild side effects such as headaches, dizziness, fatigue, nausea, and digestive discomfort like diarrhea or stomach upset.
If you are looking for a high-quality PQQ-Na2 Powder manufacturer with whom you can establish a long-term, stable partnership, then Shaanxi Medibridge Biotech Co., Ltd. would be your best business partner. Don't hesitate to contact us at hi@medibridgeapi.com.
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