IFSCC Presentation Examines Cellular Ageing
The research was presented as a poster at the IFSCC Congress, held from September 28 to October 1, 2026. Seiwa Kasei subsequently announced the work on October 14. The presentation investigated whether HAZUMI-HADA could influence senescent fibroblasts and the impaired formation of type I collagen fibers associated with the experimental model. By examining the cells responsible for producing dermal matrix components, the study extends the ingredient's research beyond general collagen-production claims toward the relationship between cellular ageing and collagen fiber formation.
Senescent Fibroblasts Provide the Research Focus
Seiwa Kasei's announcement identifies fibroblast senescence as an important consideration in skin ageing research. The company explains that senescent fibroblasts can influence neighboring cells, potentially contributing to changes in the dermal environment. Against this background, its researchers evaluated HAZUMI-HADA in senescent fibroblasts rather than limiting the investigation to normally functioning cells. This approach addresses a specific question: whether the ingredient can modify an ageing-associated cellular state alongside changes in collagen fiber formation. The public summary does not disclose the complete experimental protocol or numerical results.
Company Reports Improved Collagen Fiber Formation
According to Seiwa Kasei, HAZUMI-HADA produced changes that the company describes as rejuvenation of senescent fibroblasts, accompanied by normalization of collagen fiber formation. The poster specifically focused on impaired type I collagen fibers. These are company-reported findings from a cellular research setting and should be interpreted within that scope. They support further investigation of the ingredient's effects on fibroblast behavior and matrix formation, while the available announcement does not establish that topical use reverses biological ageing or produces equivalent changes in human skin.
Upcycled Fish Scales Underpin Ingredient Development
HAZUMI-HADA is an established collagen-derived cosmetic ingredient developed using upcycled fish scales, according to Seiwa Kasei. Its listed INCI composition comprises Potassium Cocoyl Hydrolyzed Collagen, Glycerin, and Water. The company positions the ingredient for maintaining skin firmness and elasticity and reports earlier investigations involving type I and type III collagen production. This background distinguishes the ingredient's source material from its research endpoints: it is a modified collagen-derived ingredient being studied for biological effects, rather than a direct replacement for the collagen fibers naturally present in skin.
New Cellular Findings Complement Earlier Evaluation
Separately from the IFSCC presentation, Seiwa Kasei's product information describes an evaluation in which panelists applied a gel containing HAZUMI-HADA to the face twice daily for six weeks, with dermal collagen density assessed. That evaluation should remain distinct from the newly reported senescent-fibroblast study because the experimental systems and endpoints differ. Together, the disclosures outline complementary research directions for the ingredient. Further assessment of the IFSCC findings would benefit from details on concentrations, exposure periods, senescence markers, controls, and quantitative collagen fiber measurements.
