Ovagen Peptide 99% is a synthetic tripeptide composed of Glu–Asp–Leu (EDL). It is manufactured by peptide synthesis, purified by HPLC, and freeze-dried into a white powder for convenient storage and laboratory handling. Owing to its short and well-defined structure, Ovagen is mainly used in research on peptide properties, molecular interactions, cell-based assays, and comparative studies of short regulatory peptides. In laboratory procurement, key quality factors include sequence verification, purity, solubility, filling accuracy, and batch documentation.
Shaanxi Medibridge for high-quality research-grade Ovagen Peptide. As a specialized peptide supplier, we provide lyophilized powder with ≥99% purity verified by HPLC, supported by lot-specific COA, MS/HPLC analytical data, and rigorous impurity control. Our products are available in quantities ranging from milligrams to bulk scale, with custom packaging options and fast worldwide shipping.
COA
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Product Name |
CAS Number |
Batch Number |
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Ovagen Peptide 99% |
9046-70-2 |
MB2601211030 |
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Manufacturer Date |
Analysis Date |
Expiry Date |
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2026/2/18 |
2026/2/20 |
2028/2/19 |
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Sample Qty Base |
Packing |
Test Method |
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3.56KGS |
10GS/bottle |
HPLC |
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Item |
Standard |
Results |
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Appearance |
White or off-white lyophilized powder |
Conforms |
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Identification (MS) |
Molecular weight 375.37 ± 1.0 |
Conforms |
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Peptide Sequence |
Glu–Asp–Leu (EDL) |
Conforms |
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Purity (HPLC) |
≥ 98.0% |
98.72% |
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Peptide Content |
≥ 95.0% |
96.50% |
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Water Content (Karl Fischer) |
≤ 8.0% |
4.80% |
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Acetate Content |
≤ 12.0% |
8.20% |
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Residual Solvents |
≤ 0.5% |
Conforms |
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Heavy Metals |
≤ 10 ppm |
Conforms |
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Bacterial Endotoxins |
≤ 10 EU/mg |
Conforms |
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Solubility |
Soluble in water |
Conforms |
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Storage |
Store in cool & dry place. keep away from strong light and heat |
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Conclusion |
The batch conforms to the IN-HOUSE standard |
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Specifications (for research use only)
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Form |
Sample Order |
Specification |
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Raw powder |
1 g |
Purity NLT 98% |
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Vials |
10 vials |
3ml / 5ml / 7ml / 15ml vials etc. |
Mechanism Of Action
Clomiphene does not directly stimulate the ovaries; instead, it acts primarily through the hypothalamic–pituitary–ovarian axis. By binding to estrogen receptors, it reduces hypothalamic sensitivity to estrogen-mediated negative feedback, leading the body to perceive estrogen levels as insufficient. This response promotes increased pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The resulting rise in gonadotropin levels supports follicular development and maturation, thereby enhancing the likelihood of ovulation.
Bioregulator Peptide Theory
Bioregulator peptide theory centers on short peptides, typically 2–4 amino acids, originally derived from healthy young animal organs and proposed to support organ-specific cellular communication and functional optimization.
- Functional Rationale
These peptides are thought to help maintain tissue homeostasis, support cellular repair, and influence age-related functional decline through regulatory effects on cell activity.
- Proposed Mechanism
Bioregulator peptides are proposed to enter cells, reach the nucleus, interact with DNA regulatory regions, and influence protein synthesis and cellular repair processes.
- Distinctive Features
Unlike many Western synthetic peptides that target defined receptors or pathways, bioregulators are described as natural peptide extracts intended to support broader cellular communication.
Research Direction
Anovulatory Infertility
Clomiphene is most commonly indicated for anovulatory infertility. In patients with ovulatory dysfunction but preserved ovarian reserve, it is widely used as a first-line or early therapeutic option to promote follicular development and increase the probability of ovulation.
Polycystic Ovary Syndrome (PCOS)
In PCOS, where infrequent or absent ovulation is common, clomiphene has long been a classic ovulation induction agent. However, recent studies suggest that letrozole may provide superior ovulation and live birth outcomes in some patients, leading many guidelines to favor letrozole as the preferred first-line treatment.
Male Reproductive Endocrinology Research
Clomiphene is also investigated in male reproductive endocrinology, particularly in cases of hypogonadotropic states or selected forms of infertility. By reducing estrogen negative feedback, it can increase endogenous LH, FSH, and testosterone levels, making it relevant for hormonal regulation studies.
Research Limitations
1. Peripheral Anti-Estrogenic Effects
Clomiphene may exert anti-estrogenic effects on peripheral tissues, including endometrial thinning and changes in cervical mucus. As a result, although ovulation may occur, the environment for fertilization and implantation may be less favorable.
2. Interindividual Response Variability
Not all patients respond adequately to clomiphene. Some exhibit clomiphene resistance, in which standard doses fail to induce ovulation. This phenomenon is particularly common among patients with polycystic ovary syndrome.
3. Risk of Multifollicular Development
Clomiphene can stimulate the development of multiple follicles, increasing the risk of multiple pregnancy, ovarian enlargement, and, in rare cases, more pronounced ovarian hyperstimulation-related effects. However, the risk of severe OHSS is generally lower than with injectable gonadotropins.
FAQ
What is Ovagen?
Investigational peptide-bioregulator discussed for ovarian/endocrine pathways.
What does Ovagen do?
Ovagen tablet is a fertility medicine used to treat female infertility by triggering ovulation in women who cannot produce eggs or have irregular cycles.
What are the benefits of Ovagen?
Ovagen works by stimulating ovulation, treating infertility caused by polycystic ovary syndrome (PCOS), and improving overall chances of conception.
What is ovarian regeneration?
Ovarian regeneration utilizes bone marrow stem cells, menstrual blood stem cells, and platelet-rich plasma (PRP) to restore ovarian function and revitalize ovaries before or after menopause.
What are the side effects of ovagen?
Common side effects of Ovagen include vomiting, dizziness, breast enlargement in males, breast pain, vasomotor flushing, enlarged ovaries, and gastrointestinal disturbances.
What are the ingredients in Ovagen?
Ovagen Tablet contains clomiphene as its active ingredient.
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