Calcium Hopantenate Powder, also known as the calcium salt form of hopantic acid, is a white to off-white crystalline powder raw material with a stable chemical identity and excellent physical properties. It is widely used in the production of health products, nutritional supplements, and functional foods. Key parameters of this compound include CAS 17097-76-6 (anhydrous form) and 76567-35-6 (hemihydrate form). The molecular formula C20H36CaN2O10 is commonly used in industrial formulations, with an average molecular weight of approximately 504.6. When sourcing raw materials and formulating ingredients, verify whether the anhydrous or hemihydrate form is present based on the batch COA and adjust other moisture content and density calculations in the formulation accordingly.
Calcium hopantenate exhibits good storage stability and is recommended to be stored in a sealed container under dry conditions at room temperature or a low temperature (depending on the packaging) to prevent changes in the crystalline water content caused by high humidity. This powder is easy to process, has no distinctive odor, and can be mixed with a variety of powders, carriers, and fillers. It is commonly used in formulation processes and for mixing capsules or solid beverages. Furthermore, it meets the common market requirements for "food grade" or "dietary supplement ingredient" and complies with general safety and purity requirements for raw material procurement, typically achieving a grade of ≥98%. This basic information makes Calcium Hopantenate an ideal choice for precise formulation design in nutritional and health products.
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COA
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Product Name |
CAS Number |
Batch Number |
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Calcium Hopantenate Powder |
17097-76-6 |
MB2605171405 |
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Manufacturer Date |
Analysis Date |
Expiry Date |
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2026/5/17 |
2026/5/18 |
2028/5/17 |
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Sample Qty Base |
Packing |
Test Method |
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75KGS |
25KG/drum |
HPLC |
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Item |
Standard |
Results |
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Appearance |
White Powder |
Conform |
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Odor |
Characteristic |
Conform |
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Assay |
≥98.0% |
98.51% |
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Particle Size |
100% pass 80mesh |
Conform |
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Moisture |
<5.0% |
Conform |
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Ash Content |
<4.0% |
Conform |
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Solvent Residue |
Eur.Pharm |
Conform |
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Total Heavy Metals |
<10 ppm |
Conform |
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Arsenic |
<1.0 ppm |
Conform |
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Lead |
<1.0 ppm |
Conform |
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Mercury |
<0.5 ppm |
Conform |
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DDT |
<0.2ppm |
Conform |
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E. Coli |
Negative |
Negative |
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GMO Status |
Complies |
GMO Free |
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Irradiation |
Complies |
Irradiation Free |
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Conclusion |
The batch conforms to the IN-HOUSE standard |
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Mechanism of Action
The pharmacological activity of Calcium Hopantenate is primarily based on the synergistic neuromodulatory effects derived from its dual structural features:
GABxAergic System Mimicry & Allosteric Modulation
Owing to the GABA moiety in its chemical structure, the compound efficiently crosses the blood-brain barrier (BBB) to target central nervous system GABA receptors-predominantly GABAB receptors along with select GABAA receptor complexes. It dampens pathologically excessive neuronal excitation, exerting anticonvulsant, anxiolytic, and mood-stabilizing effects without inducing the marked muscle relaxation or profound central nervous system depression typical of potent full GABA agonists.
Dopaminergic & Cholinergic Pathway Modulation
Research indicates that Hopantenate regulates the sensitivity of dopamine D2 receptors within the striatum and cerebral cortex, thereby enhancing dopaminergic neurotransmission. This exerts a positive impact on cognitive functions, sustained attention, and behavioral regulation. Concurrently, it acts synergistically on the cholinergic nervous system to promote nootropic outcomes.
Cerebral Bioenergetics & Anti-Hypoxic Protection
As a pantothenic acid homolog, it participates in Coenzyme A (CoA)-related metabolic precursor pathways, optimizing the cerebral utilization efficiency of glucose and oxygen to stimulate ATP synthesis. Under conditions of cerebral ischemia or hypoxia, it significantly attenuates intracellular lactate accumulation and protects mitochondrial function, demonstrating robust neuroprotective properties.
Pantothenate Inhibition
Despite Hopantenate's overall low systemic toxicity, its strong structural homology to D-pantothenic acid allows high-dose or long-term exposure to competitively inhibit endogenous pantothenate utilization. In rare instances, this can disrupt mitochondrial fatty acid β-oxidation due to the depletion of active Coenzyme A (CoA) pools.
Pharmacological Properties & Research Applications
Cognitive Enhancement & Nootropic Effects
Memory & Learning Fortification: Improves age-related, traumatic, or chronic ischemic memory decline and cognitive slowing by enhancing cortical neurometabolism and modulating cholinergic/dopaminergic signaling.
Attentional Focus: Frequently investigated for managing attention deficits, neurasthenia, and chronic mental fatigue.
Neuroprotection & Anti-Hypoxia
Demonstrates the capacity to suppress neuronal apoptosis, scavenge excessive free radicals, and maintain cell membrane integrity in experimental models of stroke, traumatic brain injury (TBI), and cerebral ischemia-reperfusion injury.
Anticonvulsant Activity & Neuromuscular Regulation
Antagonizes seizures induced by electrical stimulation or chemical convulsants (such as pentylenetetrazol).
Balances central inhibition and excitation in research surrounding extrapyramidal dysfunctions, including movement disorders and the alleviation of extrapyramidal side effects.
Pediatric & Geriatric Neurology
Pediatric Research: Evaluated for neuro-developmental delays, mild intellectual impairment, attention-deficit/hyperactivity syndrome (ADHD), and nocturnal enuresis in pediatric cohorts.
Geriatric Research: Applied as a therapeutic or supportive candidate in studies targeting cerebral arteriosclerosis, vascular dementia, and post-traumatic brain injury sequelae.
Potential Research Applications and Positioning
More appropriate professional positioning for calcium hopantenate includes:
- Raw material for neuropharmacological research: Investigating the relationship between GABA-related signaling and behavioral or cellular endpoints.
- Tool compound for CoA metabolism: Studying pantothenic acid utilization, CoA synthesis, and metabolic stress.
- Subject for analytical method development: Establishing methods to differentiate it from pantothenic acid, calcium pantothenate, and related metabolites.
- Case study in drug R&D history: Examining how early pharmacological conclusions were reinterpreted in light of new mechanistic insights and safety data.
FAQ
What is hopantenate calcium used for?
Hopantenate calcium is a derivative of pantothenic acid (vitamin B5) combined with GABA, acting as a central nervous system depressant and nootropic agent.
Which powder is best for calcium?
Calcium citrate powder is generally the best and most absorbable option for a powdered supplement.
Is Calcium Pantothenate safe to take?
Calcium pantothenate, a common supplemental form of vitamin B5, is generally safe and well-tolerated for most people when taken at recommended doses.
What is another name for calcium pantothenate?
Calcium pantothenate is most commonly known as Vitamin B5 or pantothenic acid calcium salt.
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